|
Symbol Name ID |
Tpm1
tropomyosin 1, alpha MGI:98809 |
| Darker colors indicate more annotations |
| Human Phenotypes | Ebstein anomaly of the tricuspid valve |
Dilated cardiomyopathy |
Hypertrophic cardiomyopathy |
Left ventricular noncompaction cardiomyopathy |
Increased left ventricular end-diastolic volume |
Mitral regurgitation |
Sudden cardiac death |
Atrial fibrillation |
Ventricular tachycardia |
Congestive heart failure |
| Disease(s) Associated with TPM1 | ||||||||||
| dilated cardiomyopathy 1Y | ||||||||||
| hypertrophic cardiomyopathy 3 |
| Mouse Phenotypes | abnormal myocardial fiber morphology |
increased myocardial fiber size |
disorganized myocardium |
myocardium hypertrophy |
heart left ventricle hypertrophy |
abnormal endocardial heart tube morphology |
abnormal heart looping |
increased heart atrium size |
abnormal heart septum morphology |
abnormal interventricular septum morphology |
increased heart weight |
cardiac hypertrophy |
abnormal heart ventricle morphology |
abnormal heart left ventricle morphology |
dilated heart ventricle |
pericardial effusion |
cardiac fibrosis |
cardiac interstitial fibrosis |
dilated cardiomyopathy |
decreased cardiac output |
abnormal diastolic filling velocity |
abnormal cardiac muscle contractility |
decreased cardiac muscle contractility |
decreased ventricle muscle contractility |
increased cardiac muscle contractility |
abnormal cardiac muscle relaxation |
decreased cardiac muscle relaxation |
abnormal heart ventricle pressure |
decreased left ventricle diastolic pressure |
decreased left ventricle systolic pressure |
increased left ventricle diastolic pressure |
decreased heart rate |
absent heartbeat |
abnormal myocardial fiber physiology |
congestive heart failure |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||
| Tpm1em1Clo/Tpm1+ | ||||||||||||||||||||||||||||||||||||
| Tg(Myh6-Tpm1*D175N)#Dfw/0 | ||||||||||||||||||||||||||||||||||||
| Tg(Myh6-Tpm1*E54K)30Dfw/0 | ||||||||||||||||||||||||||||||||||||
| Tg(Myh6-Tpm1*E54K)67Dfw/0 | ||||||||||||||||||||||||||||||||||||
| Tg(Myh6-Tpm1*E180G)57Dfw/0 | ||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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